A SYNERGISTIC MIXTURE OF: Valerian Extract (Valeriana officinalis), White Willow Extract (Salix alba), Passion Flower Extract (Passiflora incarnata), Calcium Citrate, Magnesium Aspartate

Other Professional Quality Joint Support Products at Physiologics Include:

Cartilage Care | Joint Formula | Glucosamine & Chondroitin with MSM and Omega 3-6-9 | CMO | MSM & Glucosamine Cream | Sam-e | Shark Cartilage| Hyaluronic Acid | Malic Acid

Click to buy at Physiologics with my Discount:
Enter My Professional ID PL01218

(Read more about Physiologics and our special discount arrangement
on our home page and our Quality Control page.)

Muscle tension and strain can affect anyone and can be due to a variety of physiological and psychological factors. MusclEase is a synergistic blend of herbs and essential minerals that works on multiple neural and biochemical levels for people experiencing occasional muscular tension related to exercise and other physical activity.* Essential minerals are combined with the highest quality herbal extracts for enhanced neuromuscular support.*

White Willow Extract
Willow bark has been used for therapeutic practices for approximately 2,000 years. Salicin and other salicylic derivatives have been identified as the components responsible for Willow bark’s biochemical effects. In general, total salicylic derivatives comprise a minimum of 1.5% of the dry weight of willow bark (American Herbal Pharmacopoeia). MusclEase standardizes Salicin to 10x this naturallyoccurring level to help ensure the full benefits of white willow are derived.

Willow bark constituents are believed to act through various mechanisms. The main mechanism providing beneficial effects is most likely through interaction with PGH-synthase. In addition, Salicin and its derivatives may affect the functioning of neutrophils to help ease overworked muscles.*

Magnesium
Each serving of MusclEase provides an excellent source of the essential mineral Magnesium. Magnesium’s role in proper muscle function cannot be understated as it is involved in most if not all energy-requiring reactions.*

Adenosine Triphosphate forms a complex with Magnesium, which is used by most or all ATP-requiring enzymes. Glycolytic enzymes such as pyruvate kinase and phosphofructokinase require magnesium. Magnesium is also needed at various points in the synthesis of DNA, RNA and protein, demonstrating its importance in muscle recovery and function.* Calcium pumps and Na,K-ATPase are usually the most sensitive to low magnesium levels, which can affect neuromuscular activity and hence muscle contraction/relaxation.*

Valerian Extract
Valerian and its principle components have been extensively studied for well over 50 years. Several natural components are believed to initiate its relaxation effects, including valerenic acid (standardized to .8% in MusclEase). Lab data indicates that valerenic acid and acetylvalerenic acid can inhibit GABA transaminase, thereby prolonging GABA’s effects on sedation in the central nervous system (Reidel/82). L-hydroxypinoresinol, another natural valerian alkaloid, has been found to possess a high affinity for the 5- HT1A receptor, which could also play a role in Valerian’s relaxing effects.*

Passion Flower Extract
Passion flower is a traditional herb used for its neurochemical sedative actions.* Beneficial effects attributed to passion flower include increase in latency of reaction, increased threshold to nociceptive stimuli of heat, and increased nervous system relaxation (Speroni/88).*

INDICATIONS
Occasional muscular tension can affect relaxation and overall quality of life. Excessive strain from physical activity is often a leading culprit and can be simultaneously affected by psychological stressors. MusclEase works not only at the level of muscle contraction/relaxation, but also upstream by interacting with the central nervous system and neuromuscular activity.*

• All active ingredients are naturally-sourced meaning no chemically-synthesized actives are utilized.
• Only standardized extracts are used to ensure consistent delivery of many of the active principles.
• Delivers not one but several ingredients implicated to play a role in neuromuscular relaxation pathways.*
• Suitable for a wide-range of clients due to its free of status for yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, artificial color, artificial flavor, and sodium (less than 5 mg per serving) as certified through analysis of raw material specification sheets.
• Tested to conform with USP standards for disintegration and microbial limits, including E. Coli and Staphylococcus screen.

CLINICAL EVIDENCE

• A randomized, double-blind, placebo-controlled study was conducted in 82 subjects. Each subject received either an active treatment, which contained 100 mg of white willow bark in combination with other traditional herbs (2x daily), or a matching placebo tablet. Results measured with analysis of paired differences revealed an improvement in comfort scores for the active treatment group as compared to the placebo group. This effect was widely attributed to the known systemic comfort promoting effects of the active ingredients with in white willow bark. (Mills/96)
• Valerian, propranolol, the combination of both, or placebo were given to subjects to measure the independent and synergistic effects on somatic and psychological activation when faced with stressful situations. 100mg of Valerian Extract (the same amount in 2 capsules of MusclEase) was found to reduce subjective feelings of somatic arousal. The authors reported that Valerian was able to induce thymoleptic effects for overall well-being. This in turn could lead to a state of relaxation in muscles and other organs affected by stress (Kohnen/88).

SUMMARY
As evidenced by laboratory and clinical investigations, ingredients within MusclEase can affect various pathways directly tied to muscle relaxation.* Only the highest grade extracts and ingredients are chosen to help bring about the beneficial effects of a truly synergistic combination.*

SUGGESTED DOSAGE
Take one (1) or two (2) capsules daily as needed, or follow the advice of your health care professional. May take up to 8 capsules daily. As a reminder, discuss the supplements and medications you take with your health care provider.

Click to buy at Physiologics with my Discount:
Enter My Professional ID PL01218